SRP8058

Tim-4 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 동의어(들): PC cell-derived growth factor, TIM4, TIMD4
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in CHO cells
• 분석: ≥98% (SDS-PAGE)
• 형태: lyophilized
• 분자량: monomer 54 kDa by calculation
• 포장: pkg of 100 μg
• 불순물: <0.06 EU/μg endotoxin, tested
• 색상: white
• UniProt 수납 번호: Q96H15
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: mouse ... Timd4(276891)

설명

일반 설명

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.

물리적 형태

Lyophilized from 0.2 μm-filtered solution in PBS.

재구성

Reconstitute at 100 μg/mL in sterile PBS.

기타 정보

The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable