추천 제품
product name
Progranulin human, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)
생물학적 소스
human
재조합
expressed in HEK 293 cells
결합
untagged
분석
>95% (SDS-PAGE)
형태
lyophilized
분자량
~65 kDa by SDS-PAGE
포장
pkg of 10 μg
저장 조건
avoid repeated freeze/thaw cycles
불순물
<0.1 EU/μg endotoxin, tested
색상
white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... GRN(2896)
일반 설명
Progranulin (PGRN) is a cysteine-rich protein with 593-amino acids and has a molecular weight of ~68.5kDa. The PGRN gene, with one non-coding exon and 12 coding exons spanning 8kb of genomic DNA, is mapped to human chromosome 17q21. The encoded protein is characterized by seven granulin-like domains, which include 7.5 highly conserved tandem repeats of a rare 12 cysteinyl residues. PGRN is predominantly expressed in rapidly cycling epithelial cells, leukocytes, neurons, and chondrocytes.
생화학적/생리학적 작용
Progranulin (PGRN) is a widely expressed pluripotent growth factor, which plays a crucial role in various processes such as development, cell cycle progression, cell motility, wound repair and inflammation. Additionally, It is also implicated in early embryogenesis, host defense, cartilage development and degradation. Mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). PGRN expression is associated with the development of various type of cancer such as breast cancer, ovarian carcinoma, and multiple myeloma. Overexpression of PGRN has been observed in neurodegenerative diseases such as microglia of Creutzfeldt-Jacob patients and in spinal cord of amyotrophic lateral sclerosis (ALS) patients.
물리적 형태
Lyophilized from 0.2 μm-filtered solution in PBS.
재구성
Reconstitute with 100 μL deionized water.
기타 정보
Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
van der Zee J
Human Mutation, 28(4), 416-416 (2007)
Progranulin in neurodegenerative disease.
Petkau TL and Leavitt BR2
Trends in Neurosciences, 37(7), 388-398 (2014)
Progranulin in frontotemporal lobar degeneration and neuroinflammation.
Ahmed Z
Journal of Neuroinflammation (2007)
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.
Tang W
Science, 332(6028), 478-484 (2011)
Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
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