SML1795

Tenofovir

≥98% (HPLC)

• 동의어(들): (R)-9-(2-Phosphonomethoxypropyl)adenine, (R)-PMPA
• 실험식(Hill 표기법): C₉H₁₄N₅O₄P
• CAS Number: 147127-20-6
• Molecular Weight: 287.21
• MDL number: MFCD00943794
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329826070
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 광학 활성: [α]/D -20 to -26°, c = 0.5 in 1 M HCl
• 색상: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O
• InChI: 1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
• InChI key: SGOIRFVFHAKUTI-ZCFIWIBFSA-N

설명

생화학적/생리학적 작용

Tenofovir has a low oral bioavailability. Hence, it is available as a prodrug called tenofovir disoproxil fumarate. Once ingested, tenofovir disoproxil fumarate is hydrolyzed to tenofovir and phosphorylated. This is then incorporated into the viral DNA which leads to chain termination. Tenofovir is also effective against hepatitis B virus.

Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. Tenofovir is an antiretroviral used for HIV treatment and prevention.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable