S0278

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

• 동의어(들): N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
• 실험식(Hill 표기법): C₁₂H₂₀N₂O₃S · HCl
• CAS Number: 959-24-0
• Molecular Weight: 308.82
• EC Number: 213-496-0
• MDL number: MFCD00242937
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278689
• NACRES: NA.77

속성

• product name: (±)-Sotalol hydrochloride, ≥98% (TLC), powder
• Quality Level: 200
• 분석: ≥98% (TLC)
• 형태: powder
• 색상: white to off-white
• solubility: H₂O: 20 mg/mL
• 주관자: Bayer
• SMILES string: Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
• InChI: 1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
• InChI key: VIDRYROWYFWGSY-UHFFFAOYSA-N
• 유전자 정보: human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)

설명

애플리케이션

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca²⁺) release and whole-cell currents in mammalian cancer cells.

생화학적/생리학적 작용

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.

Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves