추천 제품
일반 설명
Neutrophil elastase (NE) is a serine protease that hydrolyzes proteins within the azurophilic granules of the neutrophils. Once secreted, it digests collagen-VI and elastin of the extracellular matrix. Neutrophil elastase is implicated in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, congenital neutropenia, and lung cancer.
특징 및 장점
Compatible with high-throughput handling systems.
적합성
Suitable for the screening of inhibitors of Neutrophil Elastase.
원리
The Neutrophil Elastase Inhibitor Screening Kit is a rapid, sensitive and high throughput assay to screen and characterize potential inhibitors of NE. NE activity is measured by hydrolyzing the substrate to yield a fluorescent product (λex = 400/λem = 505 nm) proportional to the enzymatic activity present.
키트 구성품 전용
제품 번호
설명
- Assay Buffer
- Substrate
- Neutrophil Elastase
- Inhibitor Control, 3 mM SPCK
Storage Class Code
10 - Combustible liquids
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
Horwitz M S, et al.
Hematology/oncology Clinics of North America, 27, 19?41-19?41 (2013)
SVSDVSSDVD
PESTICIDES null
Neutrophil elastase as a target in lung cancer.
Moroy G, et al.
Anticancer Agents in Medicinal Chemistry, 12, 565?579-565?579 (2012)
Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
Sjo P, et al.
Future medicinal chemistry, 4(5), 651-660 (2012)
DWQDWQCW
FWQFQWFW
13th ACS Winter Fluorine Conference, paper No. 8 null
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