MAK213

Neutrophil Elastase Inhibitor Screening Kit

Sufficient for 100 Fluorometric tests

• 동의어(들): Neutrophil Elastase Inhibition Assay Kit
• EC Number: 232-670-7
• UNSPSC 코드: 12352200
• NACRES: NA.25

속성

• 검출 방법: fluorometric
• 저장 온도: −20°C
• 유전자 정보: human ... ELANE(1991) ; mouse ... ELANE(50701) ; rat ... ELANE(299606)

설명

일반 설명

Neutrophil elastase (NE) is a serine protease that hydrolyzes proteins within the azurophilic granules of the neutrophils. Once secreted, it digests collagen-VI and elastin of the extracellular matrix. Neutrophil elastase is implicated in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, congenital neutropenia, and lung cancer.

특징 및 장점

Compatible with high-throughput handling systems.

적합성

Suitable for the screening of inhibitors of Neutrophil Elastase.

원리

The Neutrophil Elastase Inhibitor Screening Kit is a rapid, sensitive and high throughput assay to screen and characterize potential inhibitors of NE. NE activity is measured by hydrolyzing the substrate to yield a fluorescent product (λ_ex = 400/λ_em = 505 nm) proportional to the enzymatic activity present.

키트 구성품 전용

• Assay Buffer
• Substrate
• Neutrophil Elastase
• Inhibitor Control, 3 mM SPCK

안전성 정보

• Storage Class Code: 10 - Combustible liquids