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Merck
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Key Documents

추가 자료

MAK034

Sigma-Aldrich

Coenzyme A (CoA) Assay Kit

sufficient for 100 colorimetric or fluorometric tests

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모든 사진(2)

About This Item

UNSPSC 코드:
12161503
NACRES:
NA.84

사용

sufficient for 100 colorimetric or fluorometric tests

검출 방법

colorimetric
fluorometric

작용기

phospholipid

관련 질환(들)

endocrinological disorders, diabetes; cancer

배송 상태

wet ice

저장 온도

−20°C

일반 설명

Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP (adenosine triphosphate). CoA plays important roles in many metabolic pathways, including the Tricarboxylic Acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example Acetyl-CoA, are critical intermediates in many metabolic reactions, particularly fatty acid and carbohydrate metabolism. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.

애플리케이션

Coenzyme A (CoA) Assay Kit has been used to measure CoA levels.

특징 및 장점

Compatible with high-throughput handling systems.

적합성

Suitable for the measurement of Coenzyme A (CoA) in a variety of biological samples including cell and tissue lysates

원리

The Coenzyme A Assay kit is an easy and convenient assay to measure the CoA level in a variety of biological samples. CoA concentration is determined by an enzymatic assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535 nm/λem = 587 nm) product, proportional to the CoA present. Typical sensitivities of detection for this kit are 0.1-10 nmol of CoA.

교체됨

제품 번호
설명
가격

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H319,H334

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1

Storage Class Code

10 - Combustible liquids

Flash Point (°F)

188.6 °F - closed cup

Flash Point (°C)

87 °C - closed cup

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.
Current Opinion in Cell Biology, 33, 125-131 (2015)
ATP-citrate lyase: a key player in cancer metabolism.
Zaidi N, et al.
Cancer Research (2012)
The subcellular localization of acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Proceedings of the National Academy of Sciences of the USA, 97(4), 1444-1449 (2000)
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Science, 291(5513), 2613-2616 (2001)
Long-Chain Fatty Acyl-CoA Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.
Rosen B C, et al.
Antimicrobial Agents and Chemotherapy, AAC-02130 (2016)
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문서

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

Fatty Acid Synthesis and Metabolism in Cancer Cells

Information on fatty acid synthesis and metabolism in cancer cells. Learn how proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sources or are synthesized by the cell.

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