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Merck
모든 사진(1)

Key Documents

추가 자료

D2069

Sigma-Aldrich

Desvenlafaxine hydrochloride

≥98% (HPLC), powder

동의어(들):

4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C16H25NO2 · HCl
CAS Number:
300827-87-6
Molecular Weight:
299.84
MDL number:
MFCD11045287
UNSPSC 코드:
12352200
PubChem Substance ID:
329798729
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated

색상

white to off-white

solubility

DMSO: >20 mg/mL
H2O: >20 mg/mL

주관자

Wyeth

저장 온도

2-8°C

SMILES string

Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2

InChI

1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H

InChI key

IMWPSXHIEURNKZ-UHFFFAOYSA-N

애플리케이션

Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.

생화학적/생리학적 작용

Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.
Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations
Kaushik G, et al.
Neuroscience Letters, 661(3), 143-148 (2017)

문서

Biogenic Amine Transporters

These distinct transporters, NET, DAT and SERT, respectively, are of particular clinical interest because they are the molecular targets for many antidepressants as well as drugs of abuse, such as cocaine and the amphetamines.

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