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Galangin

autophagy inducing flavonoid

• 동의어(들): 3,5,7-Trihydroxyflavone, Norizalpinin
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 548-83-4
• Molecular Weight: 270.24
• Beilstein: 272179
• EC Number: 208-960-4
• MDL number: MFCD00006833
• UNSPSC 코드: 41116107
• PubChem Substance ID: 57648294
• NACRES: NA.79

속성

• 분석: ≥95% (HPLC)
• 형태: powder
• 색상: yellow
• mp: 214-215 °C (lit.)
• SMILES string: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
• InChI key: VCCRNZQBSJXYJD-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

설명

일반 설명

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

애플리케이션

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

생화학적/생리학적 작용

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves