MABT859M

Anti-CDCP1 (CD318) Antibody, clone 8A2

clone 8A2, from mouse

• 동의어(들): CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with src kinases, CD318
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 8A2, monoclonal
• 종 반응성: human
• 포장: antibody small pack of 25 μg
• 기술: flow cytometry: suitable
• 동형: IgG2bκ
• NCBI 수납 번호: NP_073753.3
• UniProt 수납 번호: Q9H5V8
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CDCP1(64866)

설명

일반 설명

CUB domain-containing protein 1 (UniProt: Q9H5V8; also known as Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with Src kinases, CD318) is encoded by the CDCP1 (also known as TRASK) gene (Gene ID: 64866) in human. CUB domain-containing protein 1 is a single-pass membrane protein that is synthesized with a 29 amino acid signal peptide, which is subsequently cleaved to generate the mature form. A soluble form of CUB domain-containing protein 1 has also been reported that is produced by proteolytic cleavage at the cell surface. CUB domain-containing protein 1 is highly expressed in mitotic cells with low expression during interphase. It is detected at highest levels in skeletal muscle and colon. Lower expression is reported in kidney, small intestine, placenta, and lung. It is also reported in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. CUB domain-containing protein 1 levels are up-regulated in a number of human tumor cell lines and in colorectal cancer, breast carcinoma and lung cancer. It is reported to be involved in cell adhesion and cell matrix association and may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation.

특이성

Clone 8A2 detects CUB domain-containing protein 1 (CDCP1) in human cells. it targets an epitope within the extracellular domain.

면역원

His-tagged recombinant fragment corresponding to 638 amino acids from the extracellular domain of human CUB domain-containing protein 1.

애플리케이션

Anti-CDCP1 (CD318), clone 8A2, Cat. No. MABT859, is a mouse monoclonal antibody that detects CUB domain-containing protein 1 (CDCP1) and has been tested for use Flow Cytometry.

Flow Cytometry Analysis: A representative lot detected CDCP1 (CD318) in one million MDA and MDA KO cells (Courtesy of the Laboratory of Feng Lin, Ph.D., Cleveland Clinic, Lerner Research Institute, Cleveland OH USA).

품질

Evaluated by Flow Cytometry in DLD1 cells.

Flow Cytometry Analysis: 1 µg of this antibody detected CDCP1 (CD318) in one million DLD1 cells.

표적 설명

92.93 kDa calculated.

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to lot specific datasheet.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable