생물학적 소스
rabbit
Quality Level
항체 형태
affinity purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
mouse, human
제조업체/상표
Chemicon®
기술
immunoprecipitation (IP): suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... STAT1(6772)
특이성
STAT′s (signal transducers and activators of transcripition) are a family of cytoplasmic latent transription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5, Stat5beta, and Stat6), Stat1, Stat3, Stat5alpha, and Stat5beta have a wide activation profile (Leonard et al. 1998; Schindler et al. 1995). STAT1 is activated by many different ligands including IFN family (IFN-alpha, IFN-beta, IFN-gamma, and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF and G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1) (Darnell 1997). STAT1 has two forms, the 91 kDa STAT1alpha and the 84 kDa STAT1beta, which are encoded by the same gene with splicing variant (Schindler et al. 1992).
면역원
Polyclonal antibody raised against a peptide corresponding to amino acids 712-750 of human STAT1alpha (Schindler et al. 1992). The corresponding sequences of mouse differ from those of the immunogenic peptide by four amino acids.
애플리케이션
Detect STAT1-α also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1-α Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IP & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Western blot: 1:1000-1:2000
Immunoprecipitation: 2 to 4 μg
Whole cell lysate from HeLa , Jurkat, or A431 cells can be used as a positive control for Western Blot and a 91 kDa band can be detected. No reaction to the 84 kDa STAT1beta.
Optimal working dilutions must be determined by end user.
Immunoprecipitation: 2 to 4 μg
Whole cell lysate from HeLa , Jurkat, or A431 cells can be used as a positive control for Western Blot and a 91 kDa band can be detected. No reaction to the 84 kDa STAT1beta.
Optimal working dilutions must be determined by end user.
물리적 형태
Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Format: Purified
저장 및 안정성
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
W J Leonard et al.
Annual review of immunology, 16, 293-322 (1998-05-23)
Cytokines and interferons are molecules that play central roles in the regulation of a wide array of cellular functions in the lympho-hematopoietic system. These factors stimulate proliferation, differentiation, and survival signals, as well as specialized functions in host resistance to
Diego E Montoya-Durango et al.
Mutation research, 665(1-2), 20-28 (2009-05-12)
Long interspersed nuclear elements (LINEs or L1 elements) are targeted for epigenetic silencing during early embryonic development and remain inactive in most cells and tissues. Here we show that E2F-Rb family complexes participate in L1 elements epigenetic regulation via nucleosomal
Kiyoshi Himmelsbach et al.
World journal of virology, 7(1), 10-20 (2018-02-23)
To identify cell culture models supportive for Zika virus (ZIKV) replication. Various human and non-human cell lines were infected with a defined amount of ZIKV Polynesia strain. Cells were analyzed 48 h post infection for the amount of intracellular and
J E Darnell
Science (New York, N.Y.), 277(5332), 1630-1635 (1997-09-12)
STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site
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