676495

VEGF Inhibitor, V1

The VEGF Inhibitor, V1 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): VEGF Inhibitor, V1, ATWLPPR
• 실험식(Hill 표기법): C₄₀H₆₁N₁₁O₉
• Molecular Weight: 839.98
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

An NRP-1-binding heptapeptide whose target was initially mistaken as VEGFR2/KDR/Flk-1 due to its binding activity to a CHO-KDR culture that was later shown to express primarily NRP-1 and little KDR. V1/A7R specifically competes against VEGF₁₆₅ binding to recombinant NRP-1 in cell-free binding assays (IC₅₀ = 60 µM), while exhibiting no activity against the interaction between NRP-1 and heparin or VEGF₁₆₅ binding to KDR, VEGFR1/Flt-1, and heparin. V1/A7R is demonstrated to inhibit VEGF-dependent angiogenesis activity in HMVEC (IC₅₀ = 0.3 µM) and HUVEC cultures in vitro, as well as in a rabbit corneal neovascularization model and in mice bearing MDA-MB-231-derived tumor in vivo.

An NRP-1-binding heptapeptide whose target was initially mistaken as VEGFR2/KDR/Flk-1 due to its binding activity to a CHO-KDR culture that was later shown to express primarily NRP-1 and little KDR. V1/A7R specifically competes against VEGF₁₆₅ binding to recombinant NRP-1 in cell-free binding assays (IC₅₀ = 60 µM), while exhibiting no activity against the interaction between NRP-1 and heparin or VEGF₁₆₅ binding to KDR, VEGFR1/Flt-1, and heparin. V1/A7R is demonstrated to inhibit VEGF-dependent angiogenesis activity in HMVEC (IC₅₀ = 0.3 µM) and HUVEC cultures in vitro, as well as in a rabbit corneal neovascularization model and in mice bearing MDA-MB-231-derived tumor in vivo.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Specifically competes against VEGF165 binding to recombinant NRP-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 60 µM for specifically competes against VEGF165 binding to recombinant NRP-1 in cell-free binding assays

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH

기타 정보

Starzec, A., et al. 2006. Life Sci.79, 2370.
Binetruy-Tournaire, R., et al. 2000. EMBO J.19, 1525.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable