520222

PPACK dihydrochloride

≥80% (HPLC), solid, thrombin inhibitor, Calbiochem^®

• 동의어(들): PPACK, Dihydrochloride
• 실험식(Hill 표기법): C₂₁H₃₁ClN₆O₃ · 2HCl
• Molecular Weight: 523.88
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: PPACK, Dihydrochloride, PPACK, Dihydrochloride, CAS 82188-90-7, is an extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.
• 설명: Merck USA index - 14, 7699
• Quality Level: 100
• 분석: ≥80% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated; protect from light
• 색상: white
• solubility: water: 100 mg/mL
• 배송 상태: ambient

설명

일반 설명

Extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M^-1S^-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H₂O (Cat. No. 508773 ).

생화학적/생리학적 작용

Cell permeable: no

Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin

Primary Target
Thrombin

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

H-D-Phe-Pro-Arg-chloromethylketone, 2HCl

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.

기타 정보

Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable