5.05277

GTS-21 Dihydrochloride (DMBX-A)

• 동의어(들): GTS-21 Dihydrochloride (DMBX-A), E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21
• 실험식(Hill 표기법): C₁₉H₂₀N₂O₂ · 2HCl
• CAS Number: 156223-05-1
• Molecular Weight: 381.30
• MDL number: MFCD00941364
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: 100 mM; H₂O: 100 mM
• 저장 온도: −20°C
• SMILES string: [Cl-].[Cl-].n1cc(ccc1)C2=NCCC\C\2=C/c3c(cc(cc3)OC)OC.[H+].[H+]
• InChI: 1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
• InChI key: BXKYFUGAAFLYJL-BXGYHSFXSA-N

설명

일반 설명

A partial agonist selective for α7 nAChRs (EC₅₀ = 10 µM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer′s disease studies.

생화학적/생리학적 작용

Primary Target
α7 nAChR

Reversible: yes

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Kox, M., et al. 2011. Br. J. Anaesth.107, 559.
Kox, M., et al., 2011. Shock.36, 5.
Rosas-Ballina, M., et al. 2009. Mol. Med.15, 195.
Briggs, A., et al. 1997. Pharmacol. Biochem. Behav.57, 231.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable