475872

MnTMPyP

Cell-permeable superoxide dismutase (SOD) mimetic.

• 동의어(들): MnTMPyP, Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
• 실험식(Hill 표기법): C₇₂H₆₅MnN₈O₁₃S₄
• Molecular Weight: 1433.53
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (TLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated; protect from light
• 색상: black
• solubility: water: 1 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O₂^{– •} (rate constant ~4 x 10⁷ M^-1 s^-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O₂^• oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.

생화학적/생리학적 작용

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

기타 정보

Izbicka, E., et al. 1999. Cancer Res.59, 639.
Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable