204882

Complement C2, Human

Complement C2, Human, is a native, single chain glycoprotein present. C2 is cleaved by the activated C1s into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment.

• 동의어(들): C2 Protein
• UNSPSC 코드: 12352202
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥90% (SDS-PAGE)
• 형태: liquid
• 특이 활성도: ≥4×10⁵ C2H50 units/mg (>=70% of the C2 activity in normal human serum on a mg/mg basis)
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles
• 불순물: C1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin, trace
• 배송 상태: wet ice
• 저장 온도: −70°C

설명

일반 설명

Native, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.

포장

Please refer to vial label for lot-specific concentration.

경고

Toxicity: Standard Handling (A)

물리적 형태

In PBS, pH 6.0.

제조 메모

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

재구성

Following initial thaw, aliquot and freeze (-70°C).

기타 정보

Attwood, J.T., et al. 2001. Acta Paediatr.90, 99.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable