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Merck
모든 사진(1)

문서

19-148

Sigma-Aldrich

Bafilomycin A1

동의어(들):

Bafilomycin A

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About This Item

UNSPSC 코드:
12352106
eCl@ss:
32160405
NACRES:
NA.41

설명

Bafilomycin A1 is a specific potent inhibitor of vacuolar-type H+-ATPases, and blocks lysosomal cholesterol transport in macrophages.

Quality Level

제조업체/상표

Upstate®

기술

activity assay: suitable (kinase)

저장 온도

−20°C

애플리케이션

Bafilomycin A1 has been used:
  • as an autophagy inhibitor to study its effect on traumatic brain injury (TBI)-induced cell death and lesions in mice
  • to treat neurons for pH luorin assays to measure endocytosis during synaptic activity
  • to block autophagy in mouse embryonic fibroblasts

생화학적/생리학적 작용

Inhibitor Type: Kinase

물리적 형태

C35H58O9

저장 및 안정성

3 years at -20°C

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


시험 성적서(COA)

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Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins, aged or malfunctioning organelles, which is essential for the intracellular homeostasis and prevention of malignant transformation. Although the processes of autophagosome biogenesis have been well illuminated, the mechanism
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Tracey Evans et al.
Methods in molecular biology (Clifton, N.J.), 1854, 1-12 (2018-06-25)
Autophagy is an intracellular degradation process that mediates the clearance of cytoplasmic components. As well as being an important function for cellular homeostasis, autophagy also promotes the removal of aberrant protein accumulations, such as those seen in conditions like neurodegeneration.
Seongju Lee et al.
Science signaling, 13(613) (2020-01-09)
Mutations in WASHC5 (also known as KIAA0196) cause autosomal dominant hereditary spastic paraplegia (HSP) type SPG8. WASHC5, commonly called strumpellin, is a core component of the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex that activates actin nucleation at endosomes.
Hang Yang et al.
Virologica Sinica, 37(3), 380-389 (2022-03-11)
The recent COVID-19 pandemic poses a global health emergency. Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor-human angiotensin converting enzyme 2 (ACE2). Here, by using lentivirus based pseudotypes bearing spike protein

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