189497

Autophagy Inducer, STF-62247

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

• 동의어(들): Autophagy Inducer, STF-62247, N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
• 실험식(Hill 표기법): C₁₅H₁₃N₃S
• CAS Number: 315702-99-9
• Molecular Weight: 267.35
• MDL number: MFCD01121974
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: beige
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
• InChI key: KATNUHQNJGNLPW-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC₅₀ = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.

포장

Packaged under inert gas

경고

Toxicity: Toxic (F)

기타 정보

Turcotte, S., et al. 2008. Cancer Cell14, 90.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 유해 및 위험 성명서: H413
• 예방조치 성명서: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2