05-1117

Anti-VEGF Antibody, clone VG1

ascites fluid, clone VG1, from mouse

• 동의어(들): Vascular permeability factor, vascular endothelial growth factor, vascular endothelial growth factor A, vascular endothelial growth factor isoform VEGF165
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: ascites fluid
• 클론: VG1, monoclonal
• 종 반응성: mouse, human, rat
• 기술: western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_033531.3
• UniProt 수납 번호: P15692
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified

설명

일반 설명

VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines.

특이성

Detects the 121, 165, and 189 amino acid isoforms of VEGF.

면역원

Recombinant human VEGF 189aa isoform

애플리케이션

Detect VEGF using this Anti-VEGF Antibody, clone VG1 validated for use in WB.

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

품질

Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected VEGF on 10 µg of NIH/3T3 cell lysate.

표적 설명

Approx. 12-28 kDa

결합

Replaces: MAB3734

물리적 형태

Unpurified

Unpurified mouse monoclonal IgG1κ in ascites fluid containing no preservatives.

저장 및 안정성

Stable for 12 months at -20°C from date of receipt.
Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

분석 메모

Control
NIH/3T3 cell lysate

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable