추천 제품
분석
>99% (TLC)
양식
powder
포장
pkg of 1 × 1 mg (700136P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 700136P
배송 상태
dry ice
저장 온도
−20°C
일반 설명
7α,27-dihydroxycholesterol (7α,27-di-OHC) is synthesized by the hydroxylation of 27-hydroxycholesterol (27-OHC). It is an oxysterol with side chains oxidized and is a structural isomer of 7α,25-dihydroxycholesterol. 7α,27-dihydroxycholesterol-d6 is a deuterated derivative of 7α,27-di-OHC.
애플리케이션
7α,27-dihydroxycholesterol-d6 has been used as a deuterated internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) for human plasma oxysterol analysis.
생화학적/생리학적 작용
7α,27-dihydroxycholesterol (7α,27-di-OHC) is a ligand for Epstein-Barr virus-induced gene 2 (EBI2). 7α27-di-OHC is implicated in neurological disease, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome and diabetes by lipidomics analysis of human cerebrospinal fluid (CSF) samples. The levels of 7α,27-di-OHC decreases in lipopolysaccharide activation.
포장
5 mL Amber Glass Screw Cap Vial (700136P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
또한 이 제품과 함께 일반적으로 구입
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
가장 최신 버전 중 하나를 선택하세요:
Barbara Sottero et al.
Free radical biology & medicine, 144, 55-71 (2019-05-30)
High amounts of cholesterol have been definitely associated with the pathogenesis of several diseases, including metabolic and neurodegenerative disorders, cardiovascular diseases, and cancer. In all these pathologies the exacerbation of pro-oxidant and inflammatory responses is a consistent feature. In this
Valentin Mutemberezi et al.
Journal of neuroinflammation, 15(1), 74-74 (2018-03-11)
Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or neuroinflammatory diseases. However, the effect of neuroinflammation on oxysterol levels has only been partially studied so far. We used an
Katharina R Beck et al.
Journal of lipid research, 60(9), 1535-1546 (2019-07-06)
Oxysterols previously were considered intermediates of bile acid and steroid hormone biosynthetic pathways. However, recent research has emphasized the roles of oxysterols in essential physiologic processes and in various diseases. Despite these discoveries, the metabolic pathways leading to the different
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