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Merck

VHL

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

동의어:
HRCA1, RCA1, VHL1, pVHL
종:
Human VHL (7428), Mouse Vhl (22346), Rat Vhl (24874), fruit fly Vhl (53433), domestic cat VHL (101092590), dog VHL (494000), chicken VHL (416117), Zebrafish vhl (791202), cow VHL (540957), sheep VHL (101122897)
UniProtKB ID:
P40337, B2RE45, Q13599, Q6PDA9
Clone ID:
  • Human(7428) Summary: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(22346) von Hippel-Lindau tumor suppressor
  • Rat(24874) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • fruit fly(53433) von Hippel-Lindau
  • domestic cat(101092590) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • dog(494000) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • chicken(416117) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • Zebrafish(791202) von Hippel-Lindau tumor suppressor
  • cow(540957) von Hippel-Lindau tumor suppressor
  • sheep(101122897) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • domestic guinea pig(100729230) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

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Antibodies

제품 번호
설명
종별 반응성
응용분야
SAB2501099
Anti-VHL antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
종별 반응성
canine, human, mouse, rat
응용분야
ELISA
immunohistochemistry
western blot
MABC14
Anti-VHL Antibody, clone 11E12, clone 11E12, from mouse,
종별 반응성
human, mouse
응용분야
immunoprecipitation (IP)
western blot
SAB4503075
Anti-VHL antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunohistochemistry
WH0007428M1
Monoclonal Anti-VHL antibody produced in mouse, clone 1G12, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
immunofluorescence
western blot
HPA068954
Anti-Vhl Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunohistochemistry

Proteins

제품 번호
설명
종
SRP2084
VHL human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
종
human

esiRNA

제품 번호
설명
종
EHU074571
MISSION® esiRNA, targeting human VHL,
종
human
EMU012571
MISSION® esiRNA, targeting mouse Vhl,
종
mouse