TBP
TATA box binding protein
동의어:
GTF2D, GTF2D1, HDL4, SCA17, TFIID
종:
Human TBP (6908), Mouse Tbp (21374), Rat Tbp (117526), fruit fly Tbp (37476), domestic cat TBP (101084200), Zebrafish tbp (368882), chicken TBP (395995), dog TBP (611193), cow TBP (516578), sheep TBP (100144760) ...더
UniProtKB ID:
Clone ID:
- Human(6908) Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
- Mouse(21374) TATA box binding protein
- Rat(117526) TATA box binding protein
- fruit fly(37476) TATA binding protein
- domestic cat(101084200) TATA box binding protein
- Zebrafish(368882) TATA box binding protein
- chicken(395995) TATA box binding protein
- dog(611193) TATA box binding protein
- cow(516578) TATA box binding protein
- sheep(100144760) TATA box binding protein
- naked mole-rat(101702646) TATA box binding protein
- domestic guinea pig(100733307) TATA box binding protein
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Antibodies
제품 번호
설명
종별 반응성
응용분야
Anti-TATA-box-binding protein Antibody, clone SL30-3-563, clone SL30-3-563, from mouse,
종별 반응성
human, mouse, rat
응용분야
ChIP
western blot
western blot
Anti-TBP from hog kidney, IgG fraction of antiserum,
종별 반응성
bovine, dog, guinea pig, human, mouse, rabbit, rat, sheep
응용분야
western blot
Anti-TBP antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot
western blot
Anti-TBP antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
종별 반응성
bovine, canine, human, mouse, pig, rat
응용분야
ELISA
western blot
western blot
Anti-TBP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry
immunohistochemistry