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Merck

PTEN

phosphatase and tensin homolog

동의어:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
종:
UniProtKB ID:
Clone ID:
  • Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
  • Mouse(19211) phosphatase and tensin homolog
  • Rat(50557) phosphatase and tensin homolog
  • fruit fly(43991) CG5671 gene product from transcript CG5671-RB
  • domestic cat(101091813) phosphatase and tensin homolog
  • dog(403832) phosphatase and tensin homolog
  • chicken(423675) phosphatase and tensin homolog
  • cow(540786) phosphatase and tensin homolog
  • sheep(101119351) phosphatase and tensin homolog
  • domestic guinea pig(100723659) phosphatase and tensin homolog
  • naked mole-rat(101714930) phosphatase and tensin homolog

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
설명
종별 반응성
응용분야
Anti-phospho-PTEN (pSer385) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
Monoclonal Anti-PTEN antibody produced in mouse, clone 3E7, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
immunofluorescence

immunoprecipitation (IP)

western blot
Anti-PTEN antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP170, affinity isolated antibody,
종별 반응성
dog, human, mouse
응용분야
flow cytometry
immunohistochemistry

western blot
Anti-PTEN antibody, Rabbit monoclonal, clone SP218, recombinant, expressed in proprietary host, affinity isolated antibody,
종별 반응성
dog, frog, human, mouse
응용분야
flow cytometry
immunohistochemistry

western blot
Anti-PTEN Antibody, clone 6B12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
human, mouse
응용분야
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot

esiRNA

Product Number
설명
MISSION® esiRNA, ,
mouse
MISSION® esiRNA, targeting human PTEN,
human