PTEN
phosphatase and tensin homolog
동의어:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
종:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), domestic cat PTEN (101091813), dog PTEN (403832), chicken PTEN (423675), cow PTEN (540786), sheep PTEN (101119351), domestic guinea pig Pten (100723659)
UniProtKB ID:
Clone ID:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- naked mole-rat(101714930) phosphatase and tensin homolog
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Antibodies
제품 번호
설명
종별 반응성
응용분야
Anti-PTEN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
종별 반응성
canine, human, mouse, rat
응용분야
ELISA
western blot
western blot
Anti-PTEN antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot
western blot
Anti-PTEN antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse
응용분야
ELISA
western blot
western blot
Anti-phospho-PTEN (pSer380/pThr382/pThr383) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN (Ab-370) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
immunohistochemistry
western blot
western blot