PRKG1
protein kinase, cGMP-dependent, type I
동의어:
1, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
종:
Human PRKG1 (5592), Mouse Prkg1 (19091), Rat Prkg1 (54286), cow PRKG1 (282004), sheep PRKG1 (101117124), sheep PRKG1 (100294616), domestic guinea pig Prkg1 (100734084), Domestic Rabbit PRKG1 (100008694), naked mole-rat Prkg1 (101708361), chicken PRKG1 (423682) ...더
UniProtKB ID:
Clone ID:
- Human(5592) Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
- Mouse(19091) protein kinase, cGMP-dependent, type I
- Rat(54286) protein kinase, cGMP-dependent, type 1
- cow(282004) protein kinase, cGMP-dependent, type I
- sheep(101117124) protein kinase, cGMP-dependent, type I
- sheep(100294616) protein kinase, cGMP-dependent, type I
- domestic guinea pig(100734084) protein kinase, cGMP-dependent, type I
- Domestic Rabbit(100008694) protein kinase, cGMP-dependent, type I
- naked mole-rat(101708361) protein kinase, cGMP-dependent, type I
- chicken(423682) protein kinase, cGMP-dependent, type I
- dog(609616) protein kinase, cGMP-dependent, type I
- Horse(100071872) protein kinase, cGMP-dependent, type I
- domestic cat(101097420) protein kinase, cGMP-dependent, type I
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Antibodies
Product Number
설명
종별 반응성
응용분야
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 5E5, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
western blot
western blot
ANTI-CGKI (CGKI BETA)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
종별 반응성
human, mouse
응용분야
immunohistochemistry
western blot
western blot
Anti-cGMP (cyclic GMP) Antibody, serum, Upstate®,
종별 반응성
all
응용분야
ELISA
immunohistochemistry
radioimmunoassay
immunohistochemistry
radioimmunoassay
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 2B3, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PRKG1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
western blot
Proteins
Product Number
설명
종
PKG1alpha active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
종
human
PRKG1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
종
human
Protein Kinase G Iβ human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution,
종
human