์ฝ˜ํ…์ธ ๋กœ ๊ฑด๋„ˆ๋›ฐ๊ธฐ
Merck

MYLK

myosin light chain kinase

๋™์˜์–ด:
AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
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UniProtKB ID:
Clone ID:
  • Human(4638) Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
  • Mouse(107589) myosin, light polypeptide kinase
  • Rat(288057) myosin light chain kinase
  • chicken(396445) myosin light chain kinase
  • dog(488012) myosin light chain kinase
  • Horse(100070482) myosin light chain kinase
  • cow(338037) myosin light chain kinase
  • naked mole-rat(101704236) myosin light chain kinase
  • Domestic Rabbit(100009143) myosin light chain kinase
  • domestic guinea pig(100714177) myosin light chain kinase
  • sheep(443334) myosin light chain kinase

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Antibodies

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Monoclonal Anti-Myosin Light Chain Kinase antibody produced in mouse, clone K36, ascites fluid,
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avian, mammals
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immunoprecipitation (IP)
microarray

western blot
Anti-MYLK antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
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human
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proximity ligation assay
western blot
Anti-MYLK antibody produced in rabbit, Prestige Antibodiesยฎ Powered by Atlas Antibodies, affinity isolated antibody,
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human
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immunofluorescence
Anti-MYLK antibody produced in rabbit, Prestige Antibodiesยฎ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
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human
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immunohistochemistry
western blot
Anti-MYLK Antibody, clone 1J2U2, Rabbit Monoclonal, ,
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human, rat
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western blot

Small Molecule - Inhibitor

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ML-7, powder,
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human

Proteins

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MLCK (1425-1776), active, GST tagged human, PRECISIOยฎ Kinase, recombinant, expressed in baculovirus infected Sf9 cells, โ‰ฅ70% (SDS-PAGE), buffered aqueous glycerol solution,
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human

esiRNA

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MISSIONยฎ esiRNA, targeting human MYLK (2),
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human
MISSIONยฎ esiRNA, targeting human MYLK (1),
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human
MISSIONยฎ esiRNA, targeting mouse Mylk,
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mouse