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Merck

MBP

myelin basic protein

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  • Human(4155) Summary: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
  • Mouse(17196) myelin basic protein
  • Rat(24547) myelin basic protein
  • chicken(396217) myelin basic protein
  • domestic cat(101096421) myelin basic protein
  • dog(476160) myelin basic protein
  • cow(618684) myelin basic protein
  • naked mole-rat(101702488) myelin basic protein
  • domestic guinea pig(100731253) myelin basic protein
  • sheep(101109407) myelin basic protein

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Antibodies

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Monoclonal Anti-MBP antibody produced in mouse, Prestige Antibodiesยฎ Powered by Atlas Antibodies, clone CL2829, purified immunoglobulin, buffered aqueous glycerol solution,
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human, mouse, rat
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immunohistochemistry
western blot
Anti-MBP antibody produced in rabbit, Prestige Antibodiesยฎ Powered by Atlas Antibodies, affinity isolated antibody,
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human
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immunofluorescence
western blot
Anti-MBP antibody produced in rabbit, Prestige Antibodiesยฎ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
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human, mouse
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immunohistochemistry
western blot
Anti-MBP, affinity isolated antibody,
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dog, guinea pig, horse, human, rabbit, rat
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western blot
Monoclonal Anti-MBP antibody produced in mouse, Prestige Antibodiesยฎ Powered by Atlas Antibodies, clone CL2819, purified immunoglobulin, buffered aqueous glycerol solution,
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human, mouse, rat
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immunofluorescence
immunohistochemistry

western blot

Proteins

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MBP, GST tagged human, recombinant, expressed in E. coli, โ‰ฅ65% (SDS-PAGE), buffered aqueous glycerol solution,
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human
MBP, Dephosphorylated, ,
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cow
Myelin Basic Protein Antigen from human brain, โ‰ฅ95% (SDS-PAGE),
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human
Myelin Basic Protein from guinea pig brain, โ‰ฅ80% (SDS-PAGE), lyophilized powder, from guinea pig brain,
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domestic guinea pig

esiRNA

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MISSIONยฎ esiRNA, targeting human MBP,
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human