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Merck

HLA-C

major histocompatibility complex, class I, C

동의어:
D6S204, HLA-JY3, HLC-C, PSORS1
종:
UniProtKB ID:
Clone ID:
  • Human(3107) Summary: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
설명
종별 반응성
응용분야
Anti-HLA-C antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, pig, rabbit
응용분야
western blot
Anti-HLA-C Antibody, clone DT9, clone DT9, from mouse,
종별 반응성
human
응용분야
flow cytometry
immunoprecipitation (IP)
Monoclonal Anti-HLA Class I-PE antibody produced in mouse, clone MEM-147, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
flow cytometry
Monoclonal Anti-HLA Class I-PE antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution,
종별 반응성
bovine, feline, human, nonhuman primates
응용분야
flow cytometry
Monoclonal Anti-HLA Class I, low endotoxin antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
flow cytometry