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Merck

HLA-A

major histocompatibility complex, class I, A

동의어:
HLAA
종:
Human HLA-A (3105)
UniProtKB ID:
P16190, O02939, O02954
Clone ID:
  • Human(3105) Summary: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

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Antibodies

제품 번호
설명
종별 반응성
응용분야
SAB4700298
Monoclonal Anti-HLA-A2 azide free antibody produced in mouse, clone BB7.2, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
flow cytometry
immunoprecipitation (IP)
SAB4700834
Monoclonal Anti-HLAClass I antibody produced in mouse, clone W6/32,
종별 반응성
bovine, cat, human, nonhuman primates
응용분야
western blot
MAB1275
Anti-HLA-ABC Common Antibody, clone 22.63.4, clone 22.63.4, Chemicon®, from mouse,
종별 반응성
human
응용분야
flow cytometry
immunocytochemistry
immunohistochemistry
SAB4701062
Monoclonal Anti-HLAABCE antibody produced in mouse, clone TP25.99SF,
종별 반응성
응용분야
flow cytometry
ZRB2491
Anti-HLA-A Antibody, clone 2K7 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
human
응용분야
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot