FAS
Fas cell surface death receptor
동의어:
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
종:
Human FAS (355), Mouse Fas (14102), Rat Fas (246097), Zebrafish fas (768248), fruit fly fas (36521), domestic cat FAS (493881), cow FAS (282488), Horse FAS (100071639), dog FAS (486469), chicken FAS (395274) ...더
UniProtKB ID:
Clone ID:
- Human(355) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
- Mouse(14102) Fas (TNF receptor superfamily member 6)
- Rat(246097) Fas cell surface death receptor
- Zebrafish(768248) Fas (TNF receptor superfamily, member 6)
- fruit fly(36521) faint sausage
- domestic cat(493881) Fas (TNF receptor superfamily, member 6)
- cow(282488) Fas (TNF receptor superfamily, member 6)
- Horse(100071639) Fas (TNF receptor superfamily, member 6)
- dog(486469) Fas (TNF receptor superfamily, member 6)
- chicken(395274) Fas (TNF receptor superfamily, member 6)
- domestic guinea pig(100726403) Fas cell surface death receptor
- naked mole-rat(101704746) Fas cell surface death receptor
- sheep(100144426) Fas (TNF receptor superfamily, member 6)
- Domestic Rabbit(100008609) Fas (TNF receptor superfamily, member 6)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Antibodies
제품 번호
설명
종별 반응성
응용분야
Anti-Fas/CD95 Antibody, clone 1F17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
human, monkey
응용분야
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-Fas Antibody (human, activating), clone CH11, clone CH11, Upstate®, from mouse,
종별 반응성
human
응용분야
flow cytometry
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-Fas Antibody (human, neutralizing), clone ZB4, clone ZB4, Upstate®, from mouse,
종별 반응성
human
응용분야
flow cytometry
neutralization
western blot
neutralization
western blot