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Merck

DUSP6

dual specificity phosphatase 6

동의어:
HH19, MKP3, PYST1
:
UniProtKB ID:
Clone ID:
  • Human(1848) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(67603) dual specificity phosphatase 6
  • Rat(116663) dual specificity phosphatase 6
  • Zebrafish(353314) dual specificity phosphatase 6
  • cow(515310) dual specificity phosphatase 6
  • Horse(100051565) dual specificity phosphatase 6
  • domestic cat(101097255) dual specificity phosphatase 6
  • dog(482594) dual specificity phosphatase 6
  • chicken(374272) dual specificity phosphatase 6
  • naked mole-rat(101697963) dual specificity phosphatase 6
  • domestic guinea pig(100720904) dual specificity phosphatase 6
  • sheep(101110315) dual specificity phosphatase 6

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Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-DUSP6 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunofluorescence

immunohistochemistry
Anti-DUSP6 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
종별 반응성
human, mouse, rat
응용분야
western blot
Anti-DUSP6 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
western blot
Anti-DUSP6 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunohistochemistry
western blot
Anti-DUSP6 Antibody, clone 1H14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
canine, human, monkey, porcine, rat
응용분야
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting mouse Dusp6,
mouse
MISSION® esiRNA, targeting human DUSP6,
human