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Merck

ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

동의어:
ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, SUR1delta2, TNDM2
종:
UniProtKB ID:
Clone ID:
  • Human(6833) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008]
  • Mouse(20927) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • Rat(25559) ATP-binding cassette, subfamily C (CFTR/MRP), member 8
  • Zebrafish(553281) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • chicken(423072) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • domestic cat(101096101) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • cow(538996) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • Horse(100071788) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • dog(485402) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • sheep(101120522) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • naked mole-rat(101705546) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • domestic guinea pig(100722700) ATP-binding cassette, sub-family C (CFTR/MRP), member 8

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Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-SUR1/ABCC8 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
종별 반응성
canine, human, mouse, rat
응용분야
ELISA
western blot
Monoclonal Anti-Sur1 - Hrp antibody produced in mouse, clone S289-16, purified immunoglobulin,
종별 반응성
hamster, mouse, rat
응용분야
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Sur1 - Atto 390 antibody produced in mouse, clone S289-16, purified immunoglobulin,
종별 반응성
hamster, mouse, rat
응용분야
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Sur1 - Percp antibody produced in mouse, clone S289-16, purified immunoglobulin,
종별 반응성
hamster, mouse, rat
응용분야
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Sur1 - Biotin antibody produced in mouse, clone S289-16, purified immunoglobulin,
종별 반응성
hamster, mouse, rat
응용분야
immunocytochemistry
immunohistochemistry

western blot

Small Molecule - Blocker

제품 번호
설명
Chlorpropamide, European Pharmacopoeia (EP) Reference Standard,
human
Nateglinide, European Pharmacopoeia (EP) Reference Standard,
human
Glyburide, United States Pharmacopeia (USP) Reference Standard,
human
Tolbutamide, European Pharmacopoeia (EP) Reference Standard,
human
Repaglinide for system suitability, European Pharmacopoeia (EP) Reference Standard,
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human ABCC8,
human
MISSION® esiRNA, targeting mouse Abcc8,
mouse