Hepatocyte Growth Factor (HGF)

Jennifer Fries

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis. HGF is the ligand for a receptor encoded by the c-met proto-oncogene. c-Met expression has been observed in tumors from many sources, including stomach, lung, breast, kidney colon, liver, and melanoma, and is associated with tumor progression and metastasis.

Hepatocyte Growth Factor (HGF)

Product Description	Source	Recombinant Host	Physical Form	Assay	Cell Type Affected	Cat. No.
Hepatocyte Growth Factor	human	Baculovirus infected High-5 cells	lyophilized powder	The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5.	renal tubular epithelial cell hepatocyte epidermal keratinocyte epidermal keratinocyte	H1404-5UG
Hepatocyte Growth Factor	human	mouse NSO cells	lyophilized powder	The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5.	hepatocyte epidermal keratinocyte renal tubular epithelial cell epidermal melanocyte	H9661-5UG

References

1. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. 2003. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 4(12):915-925. https://doi.org/10.1038/nrm1261

2. Ma PC. 2003. 22(4):309-325. https://doi.org/10.1023/a:1023768811842

3. Zhang Y, Vande Woude GF. 2003. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J. Cell. Biochem.. 88(2):408-417. https://doi.org/10.1002/jcb.10358