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  • Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT

Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT

British journal of pharmacology (2017-10-24)
Roger G Pertwee, Erin M Rock, Kelsey Guenther, Cheryl L Limebeer, Lesley A Stevenson, Christeene Haj, Reem Smoum, Linda A Parker, Raphael Mechoulam
PMID29057454
ABSTRACT

The aim of this study was to compare the abilities of cannabidiolic acid methyl ester (HU-580) and cannabidiolic acid (CBDA) to enhance 5-HT We investigated the effects of HU-580 and CBDA on (i) activation by 8-hydroxy-2-(di-n-propylamino)tetralin of human 5-HT HU-580 and CBDA increased the E HU-580 is more potent than CBDA at enhancing 5-HT