Skip to Content
Merck

Biodegradable long-circulating polymeric nanospheres.

Science (New York, N.Y.) (1994-03-18)
R Gref, Y Minamitake, M T Peracchia, V Trubetskoy, V Torchilin, R Langer
ABSTRACT

Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these limitations, monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks. The nanospheres exhibited dramatically increased blood circulation times and reduced liver accumulation in mice. Furthermore, they entrapped up to 45 percent by weight of the drug in the dense core in a one-step procedure and could be freeze-dried and easily redispersed without additives in aqueous solutions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(D,L lactide), PEG average Mn 5000, PDLLA average Mn 20000
Sigma-Aldrich
Poly(D,L-lactide-co-glycolide)(50:50)-b-poly(ethylene glycol), 10k-2k
Sigma-Aldrich
Carboxylic acid-poly(ethylene glycol)-b-poly(D,L lactide), PEG average Mn 5,000, PDLA average Mn 55,000
Sigma-Aldrich
Carboxylic acid-poly(ethylene glycol)-b-poly(D,L lactide), PEG average Mn 5,000, PDLA average Mn 16,000
Sigma-Aldrich
Poly(D,L-lactide-b-glycolide) lactide:glycolide 75:25, amine (dihydrazide) terminated, average Mn 12,000
Sigma-Aldrich
Poly(lactide-co-glycolide)-Rhodamine B, lactide:glycolide 50:50, Mn 10,000-30,000
Sigma-Aldrich
3arm-poly(lactide-co-glycolide), average Mn 38,000-60,000, lactide:glycolide 55:45
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(D,L lactide), PEG average Mn 5000, PDLA average Mn 50000
Sigma-Aldrich
Poly(lactide-co-glycolide)-Flamma Fluor near-IR, lactide:glycolide (50:50), Mn 20,000-30,000
Sigma-Aldrich
Poly(lactide-co-glycolide)-fluorescein, lactide:glycolide 50:50, Mn 10,000-20,000
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 5,000, PLGA Mn 15,000, lactide:glycolide 50:50
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 5,000, PLGA Mn 5,000, lactide:glycolide 50:50
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 5,000, PLGA Mn 10,000, lactide:glycolide 50:50
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 5,000, PLGA Mn 20,000, lactide:glycolide 50:50
Sigma-Aldrich
Poly(D,L-lactide-b-glycolide) lactide:glycolide 50:50, amine terminated, average Mn 5,000
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 80:20
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 2,000, PLGA Mn 3,000, lactide:glycolide 50:50
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 50:50
Sigma-Aldrich
4arm-poly(lactide-co-glycolide), average Mn 38,000-60,000, lactide:glycolide 55:45
Sigma-Aldrich
N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(D,L lactide), PEG average Mn 5,000, PDLA average Mn 16,000
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 5,000, PLGA average Mn 10,000, lactide:glycolide 80:20
Sigma-Aldrich
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG average Mn 5,000, PLGA average Mn 5,000, lactide:glycolide 80:20