- Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.
Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.
Bioorganic & medicinal chemistry letters (2006-03-15)
Jin Hee Ahn, Seung Jun Kim, Woul Seong Park, Sung Yun Cho, Jae Du Ha, Sung Soo Kim, Seung Kyu Kang, Dae Gwin Jeong, Suk-Kyeong Jung, Sang-Hyeup Lee, Hwan Mook Kim, Song Kyu Park, Ki Ho Lee, Chang Woo Lee, Seong Eon Ryu, Joong-Kwon Choi
PMID16530413
ABSTRACT
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.
MATERIALS