- The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Bioorganic & medicinal chemistry letters (2005-11-02)
Andrew K Takle, Murray J B Brown, Susannah Davies, David K Dean, Gerraint Francis, Alessandra Gaiba, Alex W Hird, Frank D King, Peter J Lovell, Antoinette Naylor, Alastair D Reith, Jon G Steadman, David M Wilson
PMID16260133
ABSTRACT
A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.
MATERIALS