Skip to Content
Merck
  • High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon.

High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon.

The American journal of tropical medicine and hygiene (2014-05-29)
Marli S Santana, Wuelton M Monteiro, Mônica R F Costa, Vanderson S Sampaio, Marcelo A M Brito, Marcus V G Lacerda, Maria G C Alecrim
ABSTRACT

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male population (X chromosome linked). The purpose of this study was to estimate the frequency of impaired fasting glucose and diabetes among G6PD-deficient persons in Manaus, Brazil, an area in the Western Brazilian Amazon to which malaria is endemic. Glucose-6-phosphate dehydrogenase-deficient males had more impaired fasting glucose and diabetes. This feature could be used as a screening tool for G6PD-deficient persons who are unable to use primaquine for the radical cure of Plasmodium vivax malaria.

MATERIALS
Product Number
Brand
Product Description

USP
Primaquine phosphate, United States Pharmacopeia (USP) Reference Standard
Primaquine diphosphate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Primaquine bisphosphate, 98%