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  • Short-step synthesis of a resveratrol derivative from commercially available 1,3-dimethoxybenzene and 4-vinylanisole.

Short-step synthesis of a resveratrol derivative from commercially available 1,3-dimethoxybenzene and 4-vinylanisole.

Bioscience, biotechnology, and biochemistry (2009-11-10)
Takashi Iijima, Hidefumi Makabe
ABSTRACT

An efficient synthesis of tri-O-methylated resveratrol is presented using an advanced Heck reaction promoted by Pd(dba)(2) in the presence of P(t-Bu)(3).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1-Bromo-3,5-dimethoxybenzene, 97%
Sigma-Aldrich
1,3-Dimethoxybenzene, ≥98%
Sigma-Aldrich
1,3-Dimethoxybenzene, ≥98%, FG