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Buffer Filtration for Bioprocessing

Capsule and cartridge filters for processing buffers

Biomanufacturing requires large volumes of buffers for different steps in downstream processing, with filter selection highly dependent on the needs of the specific process step. For non-critical steps we offer bioburden reduction filters for superior process economics, while our sterilizing-grade buffer filters deliver fast flow and extended throughput for superior process efficiency. For some biomanufacturing operations, our virus retentive filters may be the best option for buffer filtration to achieve process safety.

All our filters are fully scalable from lab-scale process development tools to pilot and production scale manufacturing, with most offered in both single-use, gamma ready capsule and cartridge formats. In addition, each filter is available with several connection options to provide flexibility for your specific process needs.

  • Milligard® PES filters contain two layers of polyethersulfone (PES) membrane that effectively reduce bioburden while providing broad chemical compatibility with superior throughput and excellent process economics. Milligard® PES 1.2/0.2 µm nominal filters typically provide ≥ 6.0 log removal of Brevundimonas diminuta, while Milligard® PES 1.2/0.45 µm typically provide ≥ 6.0 log removal of Serratia marcescens.
  • Millipore Express® PHF (Process, High Flux) filters contain a single layer of 0.2 µm sterilizing-grade polyethersulfone (PES) membrane and provide broad chemical compatibility with high flux and extended throughput offering improved process economics.
  • Millipore Express® SHF (Sterile, High Flux) filters contain a single layer of 0.2 µm sterilizing-grade polyethersulfone (PES) membrane and provide broad chemical compatibility with high flux and extended throughput. Each filter is integrity tested during manufacturing.
  • Millipore Express® SHC (Sterile, High Capacity) filters contain two layers (0.5/0.2 µm) of polyethersulfone (PES) membrane and provide sterilizing-grade performance, broad chemical compatibility and superior capacity for plugging streams. Each filter is integrity tested during manufacturing.
  • 0.22 µm Durapore® filters contain a single layer of 0.22 µm polyvinylidene fluoride (PVDF) membrane and are low-binding, non fiber releasing with low extractables. Each filter is integrity tested during manufacturing.
  • Viresolve® Barrier capsule filters contain virus retentive PES membranes and offer high flux virus filtration. These filters offer ≥ 3.0 log removal of parvovirus, ≥ 6.0 log removal of mycoplasma and sterilizing-grade performance. Each filter is integrity tested during manufacturing.

Related Product Resources

Guide: Durapore Family Guide
Application Note: Buffer Mixing Optimization
Application Note: Bioburden Reduction and Particulate Retention Using Milligard® PES Filters
Application Note: Recommendations for Steam-in-place Sterilization of Filtration Trains Containing Milligard® PES Prefilters
Application Note: Viresolve® Barrier Filters Performance Guide
Poster: Improve Process Efficiency in Bioprocess Streams by Prefiltration Optimization and Bioburden Reduction

Simplifying Your Regulatory Compliance

Each filter is supported by comprehensive documentation for compliance with regulatory requirements. Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements and regulatory information in a readily available format to simplify your compliance needs.

These filters complement our broad portfolio of chemicals, buffer concentrates and delivery systems, providing a complete buffer preparation solution supported with decades of technical expertise in order to assure your process success.

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