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U2875

Uric acid sodium salt

Name: Uric acid sodium salt
Brand: SIGMA

Synonym(s):

2,6,8-Trihydroxypurine, Sodium acid urate

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About This Item

Linear Formula:

C₅H₃N₄O₃Na

CAS Number:

1198-77-2

Molecular Weight:

190.09

EC Number:

214-838-1

MDL number:

MFCD00067310

UNSPSC Code:

41106305

PubChem Substance ID:

24900636

NACRES:

NA.51

biological source

microbial
synthetic

Assay

11.0-13.0% anhydrous basis (Sodium, ICP)

form

powder

solubility

1 M NaOH: 25 mg/mL, clear, colorless to faintly yellow

SMILES string

[Na].O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3.Na.H/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;

InChI key

IHMJZGFANDMEJM-UHFFFAOYSA-N

Related Categories

Biochemicals

Nucleosides and Nucleotides

Application

Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

Biochem/physiol Actions

Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid. Sodium urate has been shown to precipitate calcium oxalate from urine. It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity. Excess sodium urate in soft tissues results in a condition referred to as tophi.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

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Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study.

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Journal of natural medicines, 75(1), 37-47 (2020-08-08)

Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not been fully understood. In the

A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog

Toutain PL, et al.

Journal of Veterinary Pharmacology and Therapeutics, 24(1), 43-55 (2001)

Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury.

Bin Zhang et al.

Cellular and molecular neurobiology, 37(5), 931-939 (2016-10-07)

Cerebral infarction (CI) is a common clinical cerebrovascular disease, and to explore the pathophysiological mechanisms and seek effective treatment means are the hotspot and difficult point in medical research nowadays. Numerous studies have confirmed that uric acid plays an important

Effects of reactive metabolites of oxygen and nitrogen on gelatinase A activity

Owens MW, et al.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 273(2), L445-L450 (1997)

Linne & Ringsrud's Clinical Laboratory Science, 429-432 (2015)

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