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SML2834

Sigma-Aldrich

SGC-CAMKK2-1

≥98% (HPLC)

Synonym(s):

2-Cyclopentyl-4-(5-(m-tolyl)furo[2,3-b]pyridin-3-yl)benzoic acid, YL-36

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About This Item

Empirical Formula (Hill Notation):
C26H23NO3
CAS Number:
2561494-76-4
Molecular Weight:
397.47
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC(C2=CN=C(OC=C3C4=CC(C5CCCC5)=C(C(O)=O)C=C4)C3=C2)=CC=C1

InChI

1S/C26H23NO3/c1-16-5-4-8-18(11-16)20-13-23-24(15-30-25(23)27-14-20)19-9-10-21(26(28)29)22(12-19)17-6-2-3-7-17/h4-5,8-15,17H,2-3,6-7H2,1H3,(H,28,29)

InChI key

TXIYVFVMXNFNRX-UHFFFAOYSA-N

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manufacturer/tradename

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manufacturer/tradename

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manufacturer/tradename

Heathrow Scientific HS2860H

feature

Holds 49 x 1.5-2.0 mL tubes

feature

Holds 64 x 1.5-2.0 mL tubes

feature

Holds 100 x 1.5-2.0 mL tubes

feature

Holds 81 x 1.5-2.0 mL tubes

packaging

pk of 12

packaging

pk of 12

packaging

pk of 12

packaging

pk of 12

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

well diam.

17.5 mm

well diam.

15 mm

well diam.

11.5 mm

well diam.

12 mm

Biochem/physiol Actions

Potent and selective CaM kinase kinase (CaMKK) inhibitor with selective affinity toward CAMKK1/2 over other kinases.
SGC-CAMKK2-1 (YL-36) is a potent and selective CaM kinase kinase (CaMKK) inhibitor (CAMKK2 IC50 = 30 nM) that inhibits C4-2 cellular AMPK phosphorylation (IC50 = 1.6 μM) with selective affinity toward CAMKK1/2 over other kinases (404-kinase panel kinome-wide Discoverx screen).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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