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H2769

Sigma-Aldrich

Anti-Hyperpolarization-Activated Cation Channel HCN2 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
MFCD02686271
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, human, rat

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:200-1:300 using rat brain tissue

UniProt accession no.

Q9UL51

storage temp.

−20°C

Gene Information

human ... HCN2(610)
mouse ... Hcn2(15166)
rat ... Hcn2(114244)

Immunogen

synthetic peptide corresponding to amino acids 147-161 of human HCN2 (with additional N-terminal cysteine). The epitope is identical in mouse.

Physical form

Lyophilized at 0.3 mg/mL from Phosphate Buffered Saline, pH 7.4, containing 1% Bovine Serum Albumin, and 0.05% Sodium Azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Ludwig et al.
The EMBO journal, 18(9), 2323-2329 (1999-05-06)
Cardiac pacemaking is produced by the slow diastolic depolarization phase of the action potential. The hyperpolarization-activated cation current (If) forms an important part of the pacemaker depolarization and consists of two kinetic components (fast and slow). Recently, three full-length cDNAs
Tigran P Norekian et al.
The Biological bulletin, 237(1), 36-47 (2019-08-24)
The pteropod mollusc Clione limacina is a feeding specialist, preying on shelled pteropods of the genus Limacina. Specialized prey-capture structures, called buccal cones, are hydraulically everted from within the mouth to capture the prey. Once captured, the prey is manipulated
B Santoro et al.
Cell, 93(5), 717-729 (1998-06-18)
The generation of pacemaker activity in heart and brain is mediated by hyperpolarization-activated cation channels that are directly regulated by cyclic nucleotides. We previously cloned a novel member of the voltage-gated K channel family from mouse brain (mBCNG-1) that contained

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