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Merck

RGS18

regulator of G-protein signaling 18

Synonyms:
RGS13
Species:
UniProtKB ID:
Gene ID:
  • Human(64407) Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(64214) regulator of G-protein signaling 18
  • Rat(289076) regulator of G-protein signaling 18
  • Zebrafish(768164) regulator of G-protein signaling 18
  • domestic cat(101089487) regulator of G-protein signaling 18
  • dog(607858) regulator of G-protein signaling 18
  • chicken(424361) regulator of G-protein signaling 18
  • cow(613624) regulator of G-protein signaling 18
  • sheep(101123221) regulator of G-protein signaling 18
  • domestic guinea pig(100716189) regulator of G-protein signaling 18
  • naked mole-rat(101702279) regulator of G-protein signaling 18

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-RGS18 antibody produced in mouse, clone 1G12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-RGS18 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-RGS18 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, human, rat
Application
western blot
Anti-RGS18 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-RGS18 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human RGS18,
Species
human