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Merck

CHRM4

cholinergic receptor, muscarinic 4

Synonyms:
HM4, M4R
Species:
Human CHRM4 (1132), Mouse Chrm4 (12672), Rat Chrm4 (25111), chicken CHRM4 (423195), cow CHRM4 (512928), domestic cat CHRM4 (101088360), dog CHRM4 (611314), sheep CHRM4 (101114554), Domestic Rabbit CHRM4 (100008791), domestic guinea pig Chrm4 (100714736)
UniProtKB ID:
P08173, B2RPP4, Q0VD60, Q4VBK7
Gene ID:
  • Human(1132) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
  • Mouse(12672) cholinergic receptor, muscarinic 4
  • Rat(25111) cholinergic receptor, muscarinic 4
  • chicken(423195) cholinergic receptor, muscarinic 4
  • cow(512928) cholinergic receptor, muscarinic 4
  • domestic cat(101088360) cholinergic receptor, muscarinic 4
  • dog(611314) cholinergic receptor, muscarinic 4
  • sheep(101114554) cholinergic receptor, muscarinic 4
  • Domestic Rabbit(100008791) cholinergic receptor, muscarinic 4
  • domestic guinea pig(100714736) cholinergic receptor, muscarinic 4
  • naked mole-rat(101726411) cholinergic receptor, muscarinic 4

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Small Molecule - Agonist

Product Number
Description
Species
O100
Oxotremorine M, solid,
Species
human
P6628
Pilocarpine nitrate salt, ≥98% (HPLC),
Species
human
A2251
Acetyl-β-methylcholine chloride, ≥98% (TLC), powder,
Species
human
P6503
Pilocarpine hydrochloride, ≥99% (titration), powder,
Species
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
B1390
Bisacodyl, analytical standard, for drug analysis,
Species
human
T9778
Tropicamide, solid,
Species
human
S1875
(−)-Scopolamine hydrobromide trihydrate, ≥98% (HPLC), powder,
Species
human
S7882
(−)-Scopolamine N-butyl bromide, ≥98% (TLC), powder,
Species
human
O2881
Oxybutynin chloride, ≥98% (TLC), powder,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
ZMS1165
Anti-CHRM4 Antibody, clone 18C7.2 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
ELISA
affinity binding assay
immunocytochemistry
western blot
MAB1578
Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2, clone 18C7.2, Chemicon®, from mouse,
Species Reactivity
monkey
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4300824
Anti-CHRM4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
MAB1576
Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 17F10.2, purified antibody, clone 17F10.2, Chemicon®,
Species Reactivity
monkey, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
A8404
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Species
human
D4526
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Species
human
51330
Harmaline, ≥95%,
Species
human, rat

Small Molecule - Ligand

Product Number
Description
Species
A138
Aminobenztropine, solid,
Species
human

esiRNA

Product Number
Description
Species
EMU046221
MISSION® esiRNA, targeting mouse Chrm4,
Species
mouse