- Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.
Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.
Neurology (2006-11-30)
C Kamm, F Asmus, J Mueller, P Mayer, M Sharma, U J Muller, S Beckert, R Ehling, T Illig, H E Wichmann, W Poewe, J C Mueller, T Gasser
PMID17130424
要旨
Recently, association of a TOR1A(DYT1)/TOR1B risk haplotype with common forms of idiopathic dystonia has been reported in the Icelandic population. Here we report a strong association of two single nucleotide polymorphisms within or in close proximity to the TOR1A 3'UTR, with the lowest p value being 0.000008, in a larger cohort of German and Austrian patients with predominantly focal sporadic dystonia.
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