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由来生物
human
リコンビナント
expressed in CHO cells
アッセイ
≥98% (SDS-PAGE)
形状
lyophilized
分子量
monomer 58 kDa by calculation
包装
pkg of 100 μg
不純物
<0.06 EU/μg endotoxin, tested
色
white
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... TIMD4(91937)
詳細
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
物理的形状
Lyophilized from 0.2 μm-filtered solution in PBS.
再構成
Reconstitute at 100 μg/mL in sterile PBS.
その他情報
The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of human IgG1.
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書(COA)
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