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由来生物
human
リコンビナント
expressed in E. coli
アッセイ
≥98% (HPLC)
≥98% (SDS-PAGE)
形状
lyophilized
分子量
~18.1 kDa
包装
pkg of 10 μg
不純物
endotoxin, tested
NCBIアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... IL33(90865)
関連するカテゴリー
詳細
IL-33 (interleukin 33) is a potent immunomodulatory cytokine that belongs to the IL-1 family, which also includes IL-1β and IL-18. This protein as first identified as a nuclear factor showing predominant expression in human high endothelial venules. IL-33 shows high expression levels in endothelial cells and epithelium, such as keratinocytes, that are in direct contact with the environment.
Recombinant human IL-33 produced from Escherichia coli is a non-disulfide-linked homodimeric, non-glycosylated polypeptide chain consisting of 160 amino acids and having a total molecular mass of 18.1kDa.
Recombinant human IL-33 produced from Escherichia coli is a non-disulfide-linked homodimeric, non-glycosylated polypeptide chain consisting of 160 amino acids and having a total molecular mass of 18.1kDa.
生物化学的／生理学的作用
IL-33 (interleukin 33) functions as an extracellular cytokine, and also translocates to the nucleus where it inhibits gene expression. It acts as a ligand for ST2/ IL-1 receptor-like 1 (growth STimulation expressed gene 2), and ST2 is expressed on cells such as CD34+ hematopoietic progenitor cells, eosinophils, basophils, T-helper 2 cell (Th2), and dendritic, NK (natural killer), endothelial and mast cells. Polymorphisms in this gene as well as its receptor are linked with atopic dermatitis, allergies and asthma. This protein is also thought to function as a profibrogenic cytokine, signaling through ST2, where it facilitates the stimulation and progression of fibrosis in different types of organs and tissues, such as pulmonary, liver, and uterine leiomyoma. In renal transplant recipients, the increased levels of IL-33 might be implicated in the pathogenesis of chronic allograft dysfunction (CAD).
物理的形状
Sterile filtered and lyophilized with 10 mM sodium phosphate, pH 7.5.
再構成
バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
PRTR
第一種指定化学物質
Jan Code
SRP4193-10UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
The Potential Role of IL-33 in Renal Transplant Recipients with Chronic Allograft Dysfunction.
Zhang J et al
Annals of Transplantation : Quarterly of the Polish Transplantation Society, 21, 611-618 (2016)
Esophageal Epithelial-Derived IL-33 Is Upregulated in Patients with Heartburn.
Sei H et al
PLoS ONE, 11(4), e0154234-e0154234 (2016)
Targeting the IL-1 family members in skin inflammation.
Jensen LE
Current Opinion in Investigational Drugs, 11(11), 1211-1220 (2010)
Ying Lei et al.
PloS one, 10(7), e0133774-e0133774 (2015-07-28)
In several clinical and experimental studies IL-33 and its receptor have been found to play important roles in the development of asthma and allergic airway inflammation. We evaluated the effects of vaccination against IL-33 in a mouse model of airway
Elizabeth A Oczypok et al.
The Journal of allergy and clinical immunology, 136(3), 747-756 (2015-05-02)
Single nucleotide polymorphisms in the human gene for the receptor for advanced glycation end-products (RAGE) are associated with an increased incidence of asthma. RAGE is highly expressed in the lung and has been reported to play a vital role in
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