SML1424

Ac-YVAD-pNA

≥98% (HPLC)

• 別名: Caspase-1 substrate (Chromogenic), N-α-acetyl-Tyr-Val-Ala-Asp-p-nitroanilide, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine
• 実験式（ヒル表記法）: C₂₉H₃₆N₆O₁₀
• CAS番号: 149231-66-3
• 分子量: 628.63
• MDL番号: MFCD00274387
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825867
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 保管温度: −20°C
• SMILES記法: O=C([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC1=CC=C(O)C=C1)=O)=O)=O)NC2=CC=C([N+]([O-])=O)C=C2
• InChI: 1S/C29H36N6O10/c1-15(2)25(34-28(42)22(31-17(4)36)13-18-5-11-21(37)12-6-18)29(43)30-16(3)26(40)33-23(14-24(38)39)27(41)32-19-7-9-20(10-8-19)35(44)45/h5-12,15-16,22-23,25,37H,13-14H2,1-4H3,(H,30,43)(H,31,36)(H,32,41)(H,33,40)(H,34,42)(H,38,39)/t16-,22-,23-,25-/m0/s1
• InChI Key: YDPNOCSPPGFBPX-XNHCRPTKSA-N

詳細

生物化学的／生理学的作用

Ac-YVAD-pNA is a very selective chromogenic substrate for caspase-1, a key mediator of inflammatory processes formerly known as interleukin (IL)-1-converting enzyme. Ac-YVAD-pNA is used to determine caspase-1 activity. Cleavage of Ac-YVAD-pNA by caspase-1 releases pNA (p-nitroanilide), which can be quantified spectrophotometrically at 405 nm.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable