SML1253

CASIN

≥98% (HPLC)

• 別名: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol, Cdc42 Activity-Specific Inhibitor
• 実験式（ヒル表記法）: C₂₀H₂₂N₂O
• CAS番号: 425399-05-9
• 分子量: 306.40
• MDL番号: MFCD01853271
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825745
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: , white to very dark brown
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: OCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3
• InChI: 1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2
• InChI Key: RXIUMAOXORBRCY-UHFFFAOYSA-N

詳細

アプリケーション

CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:

• to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cells
• to study its effects on mice jejunum
• to study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice

生物化学的／生理学的作用

CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable