SML1157

Eact

≥98% (HPLC)

• 別名: 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide
• 実験式（ヒル表記法）: C₂₂H₂₄N₂O₅S
• CAS番号: 461000-66-8
• 分子量: 428.50
• MDL番号: MFCD03115431
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825687
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=CC(OC)=C(OC)C(OC)=C1)N(CCOC)C2=NC(C3=CC=CC=C3)=CS2
• InChI: 1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3
• InChI Key: ZUXNHFFVQWADJL-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

E_act activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC. E_act stimulates CaCC conductance in salivary gland cells and submucosal airway epithelial cells. The compound E_act also stimulates submucosal gland secretion in human bronchial tissue and smooth muscle contraction in mouse intestine.

In rat arterial myocytes, Eact [3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide] helps to activate chloride current and prevents estradiol synthesis in cultured mouse granulosa cells. It is a small molecule activator of TMEM16A (transmembrane member 16A), that activates TRPV1 (transient receptor potential cation channel subfamily V member 1) and generates pain and itch related symptoms. Eact also initiates endogenous TRPV1 expressed by DRG (dorsal root ganglion) neurons.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable