SML0213

MC2050 hydrate

≥98% (HPLC)

• 別名: 2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate
• 実験式（ヒル表記法）: C₁₉H₂₁N₅OS·2HCl · xH₂O
• 分子量: 440.39 (anhydrous basis)
• MDL番号: MFCD21608523
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825234
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: H₂O: ≥5 mg/mL at warmed to 60 °C
• 保管温度: 2-8°C
• SMILES記法: O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
• InChI: 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
• InChI Key: LMZZPRHHBPFDGE-UHFFFAOYSA-N

詳細

アプリケーション

MC2050 hydrate may be used in cell signaling studies.

生物化学的／生理学的作用

MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀ for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

特徴および利点

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable